TyK2-IN-2

CAT: 0804-HY-101762-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-101762-01Size:10 mM - 1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases[1].
CAS Number
[2098466-94-3]
UNSPSC
12352005
Target
JAK; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TYK2-IN-2.html
Purity
99.71
Solubility
DMSO : ≥ 25 mg/mL
Smiles
CNC1=CC(NC2=CC(C)=CC(C)=C2)=NN3C1=NC=C3C(N)=O
Molecular Formula
C16H18N6O
Molecular Weight
310.35
References & Citations
[1]Moslin R, et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8 (4) :700-712.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4; Tyk2

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