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Tyk2-IN-22

CAT: 0804-HY-168339Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168339Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation[1].
CAS Number
933667-23-3
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tyk2-in-22.html
Smiles
O=C1N2C(NC(C3=CC=C(Cl)C=C3)=N2)=NC(CN4CCOCC4)=C1
Molecular Formula
C16H16ClN5O2
Molecular Weight
345.78
References & Citations
[1]Istanbullu H, et al. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold[J]. Bioorganic Chemistry, 2024, 148: 107430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK3; Tyk2

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