Tyk2-IN-22

Tyk2-IN-22

• CAS Number: 933667-23-3
• UNSPSC Description: Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation[1].
• Target Antigen: JAK
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tyk2-in-22.html
• Smiles: O=C1N2C(NC(C3=CC=C(Cl)C=C3)=N2)=NC(CN4CCOCC4)=C1
• Molecular Weight: 345.78
• References & Citations: [1]Istanbullu H, et al. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold[J]. Bioorganic Chemistry, 2024, 148: 107430.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported