JAK1-IN-4

CAT: 0931-T15606-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T15606-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2091134-35-7

Target

JAK

Related Pathways

Stem Cells, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

Bioactivity

JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively) . JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM) .

Smiles

N(C([C@@H](C)N1C[C@@H](C)N(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC=5C(OC)=NN(C)C5)=NC=C4F)=CC=C2

Molecular Formula

C26H32FN9O2

Molecular Weight

521.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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A18821-50	JAK1-IN-4 50mg
A18821-10	JAK1-IN-4 10mg
A18821-25	JAK1-IN-4 25mg
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JAK1-IN-4

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