Tyk2-IN-3

• Description:

  Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM.

• UNSPSC:

  12352005

• Target:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Tyk2-IN-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1C=NC2=C1C(N=C(C3=CC=CC([C@@H](C)NC(C4=C(S(=O)(C)=O)C=CC=C4)=O)=C3)S5)=C5N=C2NC

• Molecular Formula:

  C25H24N6O3S2

• Molecular Weight:

  520.63

• References & Citations:

  [1]Tokarski JS, et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J Biol Chem. 2015 Apr 24;290 (17) :11061-74.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Tyk2

• CAS Number:

  [1779493-12-7]