Gcase activator 3

• Description :

  Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1].

• UNSPSC :

  12352005

• Target :

  Glycosidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/gcase-activator-3.html

• Purity :

  99.67

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN(C[C@@H]1OC2=CC=CC=C2OC1)C3=C4C=CC=CC4=NC(C5=CC=CN=C5)=N3

• Molecular Formula :

  C23H20N4O2

• Molecular Weight :

  384.43

• References & Citations :

  [1]Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62 (3) :1218-1230.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2270984-21-7]