Gcase activator 3
CAT:
804-HY-160426
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Gcase activator 3
- CAS Number: 2270984-21-7
- UNSPSC Description: Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1].
- Target Antigen: Glycosidase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/gcase-activator-3.html
- Solubility: 10 mM in DMSO
- Smiles: CN(C[C@@H]1OC2=CC=CC=C2OC1)C3=C4C=CC=CC4=NC(C5=CC=CN=C5)=N3
- Molecular Weight: 384.43
- References & Citations: [1]Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported