TFEB activator 3

• Description :

  TFEB activator 3 (compound 45) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h) . TFEB activator 3 plays an important role in Alzheimer’s disease (AD) . TFEB activator 3 can pass blodd brain barrier[1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tfeb-activator-3.html

• Smiles :

  C12=C(C(NCC2)CCC3=CNC4=C3C=CC=C4)C=C5C(OCO5)=C1

• Molecular Formula :

  C20H20N2O2

• Molecular Weight :

  320.39

• References & Citations :

  [1]Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67 (11) :8836-8861.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3027413-48-2]