GCase modulator-1

• Description :

  GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Glycosidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gcase-modulator-1.html

• Purity :

  97.0

• Solubility :

  DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C1(C2=NC3=C(C(N4CC5=C(CC4)C=CC=C5)=N2)C=CC=C3)=CN=CC=C1

• Molecular Formula :

  C22H18N4

• Molecular Weight :

  338.41

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62 (3) :1218-1230.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [796079-91-9]