GCase modulator-1

GCase modulator-1

• CAS Number: 796079-91-9
• UNSPSC Description: GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM)[1].
• Target Antigen: Glycosidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/gcase-modulator-1.html
• Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C1(C2=NC3=C(C(N4CC5=C(CC4)C=CC=C5)=N2)C=CC=C3)=CN=CC=C1
• Molecular Weight: 338.41
• References & Citations: [1]Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported