PKG1α activator 3

• UNSPSC Description:

  PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].

• Target Antigen:

  PKG

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pkg1α-activator-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1

• Molecular Weight:

  545.41

• References & Citations:

  [1]Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65(15):10318-10340.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2773367-58-9