PKG1α activator 3

PKG1α activator 3

• CAS Number: 2773367-58-9
• UNSPSC Description: PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].
• Target Antigen: PKG
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pkg1α-activator-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1
• Molecular Weight: 545.41
• References & Citations: [1]Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65(15):10318-10340.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported