PKG1α activator 3

• Description :

  PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM) . PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].

• UNSPSC :

  12352005

• Target :

  PKG

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pkg1α-activator-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1

• Molecular Formula :

  C27H26Cl2N2O6

• Molecular Weight :

  545.41

• References & Citations :

  [1]Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65 (15) :10318-10340.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2773367-58-9]