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PKM2 activator 3

CAT: 0804-HY-147397Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147397Size:1 Each
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Description
PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer[1]. (AC50: the concentration which gives 50% activation of enzyme.)
CAS Number
1346113-84-5
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkm2-activator-3.html
Solubility
10 mM in DMSO
Smiles
FC1=C(Cl)C=C(NS(=O)(C(C=C2CC3)=C(F)C=C2NC3=O)=O)C=C1
Molecular Formula
C15H11ClF2N2O3S
Molecular Weight
372.77
References & Citations
[1]Walsh MJ, et al. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6322-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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