Gcase activator 2

• Description :

  Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM) . Gcase activator 2 induces GCase dimerizatio (both K-type and V-type) . And Gcase activator 2 has low metabolic clearance in human and mouse[1].

• UNSPSC :

  12352005

• Target :

  Glycosidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/gcase-activator-2.html

• Concentration :

  10mM

• Purity :

  99.23

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(N1CCC(C2=CC3=NC(C4=CC=C(OC)C=C4)=CN=C3N2C)CC1)=O

• Molecular Formula :

  C21H24N4O2

• Molecular Weight :

  364.44

• References & Citations :

  [1]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442. |[2]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2759897-35-1]