Gcase activator 2

• Description:

  Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM) . Gcase activator 2 induces GCase dimerizatio (both K-type and V-type) . And Gcase activator 2 has low metabolic clearance in human and mouse[1].

• UNSPSC:

  12352005

• Target:

  Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/gcase-activator-2.html

• Concentration:

  10mM

• Purity:

  99.23

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (N1CCC (C2=CC3=NC (C4=CC=C (OC) C=C4) =CN=C3N2C) CC1) =O

• Molecular Formula:

  C21H24N4O2

• Molecular Weight:

  364.44

• References & Citations:

  [1]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442. |[2]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2759897-35-1