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Glucokinase activator 3

CAT: 0804-HY-144287-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144287-01Size:5 mg
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Description
Glucokinase activator 3 is an orally active Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes[1].
CAS Number
1001417-92-0
UNSPSC
12352005
Target
Glucokinase; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glucokinase-activator-3.html
Concentration
10mM
Purity
98.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(CP(OCC)(OCC)=O)=CS1)C2=CC(OC3=CC=C(S(=O)(C)=O)C=C3)=CC(O[C@@H](C)COC)=C2
Molecular Formula
C26H33N2O9PS2
Molecular Weight
612.65
References & Citations
[1]Shi Y, et al. Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3- (3- ((5- (Azetidine-1-carbonyl) pyrazin-2-yl) oxy) -5-isopropoxybenzamido) -1H-pyrazol-1-yl) methyl) phosphonate (BMS-820132) . J Med Chem. 2022, 65 (5) :4291-4317.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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