PROTAC (H-PGDS) -8

• Description :

  PROTAC (H-PGDS) -8 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a IC50 of 0.14 μM[1].

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor; PROTACs

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; PROTAC

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/protac-h-pgds-8.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=C(N=C3)OC4=CC=CC=C4)=O)N5CCN(CC5)C6=C(C7=CC=C6)C(N(C7=O)C8CCC(N(C8=O)C)=O)=O

• Molecular Formula :

  C41H40N8O7

• Molecular Weight :

  756.81

• References & Citations :

  [1]Yokoo H, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem. 2021 Nov 11;64 (21) :15868-15882.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2761281-51-8]