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PROTAC SMARCA2 degrader-8

CAT: 0804-HY-161882Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161882Size:1 Each
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Description
PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells[1].
CAS Number
2669027-50-1
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-8.html
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C4=CC=NC(N5CCN(C6=CC(C7=CC=CC=C7O)=NN=C6N)CC5)=C4
Molecular Formula
C43H50N10O5S
Molecular Weight
818.99
References & Citations
[1]Wurz RP, et al. Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun. 2023 Jul 13;14 (1) :4177.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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