PROTAC SMARCA2 degrader-8

PROTAC SMARCA2 degrader-8

• CAS Number: 2669027-50-1
• UNSPSC Description: PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-8.html
• Smiles: O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C4=CC=NC(N5CCN(C6=CC(C7=CC=CC=C7O)=NN=C6N)CC5)=C4
• Molecular Weight: 818.99
• References & Citations: [1]Wurz RP, et al. Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation. Nat Commun. 2023 Jul 13;14(1):4177.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported