PROTAC CDK9 degrader-8

PROTAC CDK9 degrader-8

• CAS Number: 2994191-89-6
• UNSPSC Description: PROTAC CDK9 degrader-8 (compound 21) is a potent PROTAC CDK9 degrader with an IC50 value of 0.01 μM. PROTAC CDK9 degrader-8 can be used in research of cancer[1].
• Target Antigen: CDK; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-cdk9-degrader-8.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NC3CCN(CCCCCCCCCCC4=CN(CCCOC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)CC3
• Molecular Weight: 903.85
• References & Citations: [1]Oluwatosin RA, et, al. Examination of the Impact of Triazole Position within Linkers on Solubility and Lipophilicity of a CDK9 Degrader Series. ACS Med. Chem. Lett. 2023, 14(7):936-42.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported