PROTAC CDK9 degrader-8

• UNSPSC Description:

  PROTAC CDK9 degrader-8 (compound 21) is a potent PROTAC CDK9 degrader with an IC50 value of 0.01 μM. PROTAC CDK9 degrader-8 can be used in research of cancer[1].

• Target Antigen:

  CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-cdk9-degrader-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NC3CCN(CCCCCCCCCCC4=CN(CCCOC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)CC3

• Molecular Weight:

  903.85

• References & Citations:

  [1]Oluwatosin RA, et, al. Examination of the Impact of Triazole Position within Linkers on Solubility and Lipophilicity of a CDK9 Degrader Series. ACS Med. Chem. Lett. 2023, 14(7):936-42.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2994191-89-6