PROTAC ERα Degrader-8

PROTAC ERα Degrader-8

• CAS Number: 3025533-68-7
• UNSPSC Description: PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC50 of 0.000006 μM in MCF7 cells[1].
• Target Antigen: Estrogen Receptor/ERR; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-erα-degrader-8.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC=C2[C@H](C3=CC=C(N([C@@]4([H])C5)[C@](CC4)([H])CC5CN6CCN(C7=CC=C8C(CN([C@@H](CCC9=O)C(N9)=O)C8=O)=C7)CC6)C=C3)[C@H](C%10=CC=CC=C%10)CCC2=C1
• Molecular Weight: 749.94
• References & Citations: [1]Relay Therapeutics, Inc. Preparation of bifunctional compounds as estrogen receptor alpha degraders and use thereof. World Intellectual Property Organization, WO2024006781 A1 2024-01-04
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported