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PROTAC (H-PGDS) -7

CAT: 0804-HY-139972-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139972-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC (H-PGDS) -7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM[1].
CAS Number
2761281-50-7
UNSPSC
12352005
Target
Molecular Glues; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/protac-h-pgds-7.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CCN(C2=CC=C(NC(C3=CN=C(OC4=CC=CC=C4)N=C3)=O)C=C2)CC1)N5CCN(C6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)CC5
Molecular Formula
C40H38N8O7
Molecular Weight
742.78
References & Citations
[1]Hidetomo Yokoo, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem. 2021 Nov 11;64 (21) :15868-15882.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DP