PROTAC BRD9 Degrader-8

PROTAC BRD9 Degrader-8

• UNSPSC Description: PROTAC BRD9 Degrader-8 (compound E5) is a PROTAC-based BRD9 degrader with a DC50 value of 16 pM. PROTAC BRD9 Degrader-8 has antiproliferation in MV4–11 cells (IC50 = 0.27 nM) and OCI-LY10 cells (IC50 = 1.04 nM)[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-brd9-degrader-8.html
• Smiles: O=C1C2=C(C(C3=CC(OC)=C(C(OC)=C3)CN4CCC(CN5CCC(CC5)C6=C7C(C8=CC=C7)=C(C=C6)N(C9C(NC(CC9)=O)=O)C8=O)CC4)=CN1C)C=CC=C2
• Molecular Weight: 767.91
• References & Citations: [1]Haiting Duan, et al. Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. J. Med. Chem. 2024, 67, 13, 11326–11353.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported