Antitumor agent-133

CAT: 0804-HY-157548Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157548Size:1 Each
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Description
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM) . Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; p62
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-133.html
Solubility
10 mM in DMSO
Smiles
COC([C@@H](NC(CN1C(C(C2=CC(Br)=CC=C21)=O)=O)=O)CCCCNC(CN3C(C(C4=CC(Br)=CC=C43)=O)=O)=O)=O
Molecular Formula
C27H24Br2N4O8
Molecular Weight
692.31
References & Citations
[1]Li Z, et al., Synthesis, biological activity evaluation and mechanism of action of novel bis-isatin derivatives as potential anti-liver cancer agents. Bioorg Med Chem Lett. 2024 Jan 13;99:129613. doi: 10.1016/j.bmcl.2024.129613
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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