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Antitumor agent-99

CAT: 0804-HY-157217Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157217Size:1 Each
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Description
Antitumor agent-99 (compound 7) is an anticancer agent targeting FRα/β and PCFT. Antitumor agent-99 inhibits R2/PCFT4 (PCFT), RT16 (FRα), and D4 (FRβ) cells with IC50s of 51.46 nM, 2.53 nM, and 2.98 nM, respectively[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-99.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(O)=O)CCC(O)=O)C1=CC=C(CCC2=C(C)NC(N=C(N3)N)=C2C3=O)S1
Molecular Formula
C19H21N5O6S
Molecular Weight
447.46
References & Citations
[1]Kaku K et al. Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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