HDAC-IN-65

• UNSPSC Description:

  HDAC-IN-65 ( compound 6) is a selective histone deacetylase (HDAC) inhibitor with IC50 value of 2.5μM. HDAC-IN-65 is a prodrug with very good bioreductive properties[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac-in-65.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=CC=C1NC(C2=NC=C(N=C2)N3CCN(CC3)CC4=CNC5=C4C=CC=C5)=O)OCC6=CN=C(N6C)[N+]([O-])=O

• Molecular Weight:

  610.62

• References & Citations:

  [1]Mohamed Abdelsalam, et al. Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells. Arch Pharm (Weinheim). 2023.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported