HDAC6-IN-65

CAT: 0804-HY-178110Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178110Size:1 Each
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Description
HDAC6-IN-65 is a selective HDAC6 inhibitor (IC50 = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC50 = 39.4 nM) . HDAC6-IN-65 can induce the accumulation of α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma[1].
CAS Number
[3028442-70-5]
UNSPSC
12352005
Target
HDAC; Histone Methyltransferase; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(N(CC1=CN=CC=C1)CC2=CC=C(C=C2)C(NO)=O)(C3=C(C=CC=C3)Cl)=O
Molecular Formula
C20H18ClN3O4S
Molecular Weight
431.89
References & Citations
[1]Olaoye OO, et al. Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 2025 Sep 11;68 (17) :18216-18229.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC3; HDAC6

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