PKM2-IN-4

PKM2-IN-4

• CAS Number: 2996165-24-1
• UNSPSC Description: Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling[1].
• Target Antigen: Pyruvate Kinase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/pkm2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: BrC1=C([Se][N+]2=C1C=C(C(OC)=O)C=C2)C3(CCCCC3)O.[Cl-]
• Molecular Weight: 453.62
• References & Citations: [1]Dimitrijevs P, et al. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. Eur J Med Chem. 2023 Sep 5;257:115504.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported