PKM2-IN-4

• UNSPSC Description:

  Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling[1].

• Target Antigen:

  Pyruvate Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/pkm2-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  BrC1=C([Se][N+]2=C1C=C(C(OC)=O)C=C2)C3(CCCCC3)O.[Cl-]

• Molecular Weight:

  453.62

• References & Citations:

  [1]Dimitrijevs P, et al. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. Eur J Med Chem. 2023 Sep 5;257:115504.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2996165-24-1