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PKM2-IN-11

CAT: 0804-HY-178441Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178441Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKM2-IN-11 is a PKM2 inhibitor (IC50 = 0.363 μM) . PKM2-IN-11 has dual mechanisms involving pyruvate kinase M2 (PKM2) inhibition and microtubule stabilization. PKM2-IN-11 can decrease PKM2 protein levels in MCF-7 cells. PKM2-IN-11 can slightly reduce reactive oxygen species (ROS) levels and significantly increase early apoptotic cells. PKM2-IN-11 induces G2/M phase arrest. PKM2-IN-11 can be used for the study of breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Pyruvate Kinase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Metabolic Disease
Smiles
CC1(C)C=CC2=C(C=CC(/C=C/C(C3=CC=C(OC)C(I)=C3)=O)=C2O)O1
Molecular Formula
C21H19IO4
Molecular Weight
462.28
References & Citations
[1]Katiyar MK, et al. Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy. Bioorg Chem. 2025 Oct;165:109008.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKM2

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