PKM2-IN-8

• Description :

  PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC50 = 0.31 μM) . PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early apoptosis and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Pyruvate Kinase

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  O=C(CN1N=C(C2=CC=C(C=CC=C3)C3=C2)N=N1)C4=CN=C5N4C=CC=N5

• Molecular Formula :

  C19H13N7O

• Molecular Weight :

  355.35

• References & Citations :

  [1]Chowdhury MG, et al. Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells. Bioorg Chem. 2025 Jan;154:108029.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported