PKM2-IN-1

PKM2-IN-1

• CAS Number: 94164-88-2
• UNSPSC Description: PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM[1].
• Target Antigen: Pyruvate Kinase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/PKM2-IN-1.html
• Purity: 99.79
• Solubility: DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: S=C(N1CCCCC1)SCC(C2=O)=C(C)C(C3=C2C=CC=C3)=O
• Molecular Weight: 345.48
• References & Citations: [1]Ning X, et al. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported