PKM2-IN-12

• Description :

  PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Endogenous Metabolite; Pyruvate Kinase; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C(C2=CC=C(Cl)C=C2)N=C(NC3=CC=C(Cl)C=C3)S1)C4=CN=C5C=CC=CN54

• Molecular Formula :

  C23H14Cl2N4OS

• Molecular Weight :

  465.35

• References & Citations :

  [1]Ghosh Chowdhury M, et al. Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer. J Med Chem. 2025 Oct 23;68 (20) :21786-21806.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PKM2