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PKM2-IN-12

CAT: 0804-HY-178748Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178748Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer[1].
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite; Pyruvate Kinase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=C(C2=CC=C(Cl)C=C2)N=C(NC3=CC=C(Cl)C=C3)S1)C4=CN=C5C=CC=CN54
Molecular Formula
C23H14Cl2N4OS
Molecular Weight
465.35
References & Citations
[1]Ghosh Chowdhury M, et al. Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer. J Med Chem. 2025 Oct 23;68 (20) :21786-21806.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKM2

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