PKM2-IN-3

• Description:

  PKM2-IN-3 is an inhibitor of PKM2 kinase with an IC50 value of 4.1 μM. PKM2-IN-3 exhibits an anti-neuroinflammatory effect by inhibiting PKM2-mediated glycolysis and NLRP3 activation[1].

• UNSPSC:

  12352005

• Target:

  Pyruvate Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pkm2-in-3.html

• Purity:

  99.44

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  COC1=C2C (OCC/C (C2=O) =C\C3=CC=C (C=C3) CC) =CC (OC) =C1

• Molecular Formula:

  C21H22O4

• Molecular Weight:

  338.40

• References & Citations:

  [1]Gao CL, et al. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. Angew Chem Int Ed Engl. 2020;59 (6) :2429-2439.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2408841-19-8