PKM2-IN-3

• Description :

  PKM2-IN-3 is an inhibitor of PKM2 kinase with an IC50 value of 4.1 μM. PKM2-IN-3 exhibits an anti-neuroinflammatory effect by inhibiting PKM2-mediated glycolysis and NLRP3 activation[1].

• UNSPSC :

  12352005

• Target :

  Pyruvate Kinase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pkm2-in-3.html

• Purity :

  99.44

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  COC1=C2C(OCC/C(C2=O)=C\C3=CC=C(C=C3)CC)=CC(OC)=C1

• Molecular Formula :

  C21H22O4

• Molecular Weight :

  338.40

• References & Citations :

  [1]Gao CL, et al. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. Angew Chem Int Ed Engl. 2020;59 (6) :2429-2439.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2408841-19-8]