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Antitumor agent-111

CAT: 0804-HY-155544Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155544Size:1 Each
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Description
Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC50=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-111.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=CC=C(F)C(Cl)=C2)C3=C(C=CC=N3)C1=O)NC4=CC=C(OC5=CC(C(NCCCN6CCOCC6)=O)=NC=C5)C(F)=C4
Molecular Formula
C34H29ClF2N6O5
Molecular Weight
675.08
References & Citations
[1]Dai J, et al. Design, synthesis and biological evaluation of 4- (4-aminophenoxy) picolinamide derivatives as potential antitumor agents. Eur J Med Chem. 2023 Sep 5;257:115499.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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