Antitumor agent-111

• UNSPSC Description:

  Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC50=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis[1].

• Target Antigen:

  c-Met/HGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-111.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN(C2=CC=C(F)C(Cl)=C2)C3=C(C=CC=N3)C1=O)NC4=CC=C(OC5=CC(C(NCCCN6CCOCC6)=O)=NC=C5)C(F)=C4

• Molecular Weight:

  675.08

• References & Citations:

  [1]Dai J, et al. Design, synthesis and biological evaluation of 4-(4-aminophenoxy)picolinamide derivatives as potential antitumor agents. Eur J Med Chem. 2023 Sep 5;257:115499.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4