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BuChE-IN-8

CAT: 0804-HY-155304Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155304Size:1 Each
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Description
BuChE-IN-8 (compound 19c) is a butyrylcholinesterase (BuChE) inhibitor with an IC50 of 559 nM. BuChE-IN-8 possesses human β-secretase (BACE1) and Aβ40 aggregation inhibitory activities. BuChE-IN-8 has significant antiamnesic properties[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-8.html
Solubility
10 mM in DMSO
Smiles
CN(C(CCN)C(NCC1=CC=C(Cl)C=C1)=O)CCOCCN2C3=C(C=CC=C3)SC4=CC=CC=C42
Molecular Formula
C28H33ClN4O2S
Molecular Weight
525.11
References & Citations
[1]Paula Zaręba, et al. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. Eur J Med Chem. 2023 Oct 7:261:115832.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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