BuChE-IN-7

• Description:

  BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/buche-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3

• Molecular Formula:

  C25H34N2O2

• Molecular Weight:

  394.55

• References & Citations:

  [1]Panek D, et al. Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies. Eur J Med Chem. 2023 Jan 18;249:115135.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BChE