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BuChE-IN-2

CAT: 0804-HY-143413Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143413Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO) . BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease[1].
CAS Number
2745118-93-6
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC(C3=CC(NC4=CC=C(OC(F)(F)F)C=C4)=NC=C3)=NO2)C=C1)CNC5=CC=C(F)C=C5
Molecular Formula
C28H20F4N6O3
Molecular Weight
564.49
References & Citations
[1]Liu T, et al. Design, synthesis, and biological evaluation of novel (4- (1,2,4-oxadiazol-5-yl) phenyl) -2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;227:113973.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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