BuChE-IN-1

• Description :

  BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE) . Butyrylcholinesterase (BuChE) is recently regarded as a biomarker in progressed Alzheimer’s disease (AD) . BuChE-IN-1 shows low cytotoxicity and high blood brain barrier (BBB) permeability. BuChE-IN-1 is a promising BuChE inhibitor for the research of AD[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/buche-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC=C(OCO2)C2=C1)N(CC3=CSC(COC4=CC=C(F)C=C4)=N3)CC(C)C

• Molecular Formula :

  C23H23FN2O4S

• Molecular Weight :

  442.50

• References & Citations :

  [1]MeiyangXi, et al. Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N- ((2- (p-tolyloxymethyl) thiazol-4yl) methyl) benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BChE

• CAS Number :

  [2669070-40-8]