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BuChE-IN-1

CAT: 0804-HY-144446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144446Size:1 Each
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Description
BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE) . Butyrylcholinesterase (BuChE) is recently regarded as a biomarker in progressed Alzheimer’s disease (AD) . BuChE-IN-1 shows low cytotoxicity and high blood brain barrier (BBB) permeability. BuChE-IN-1 is a promising BuChE inhibitor for the research of AD[1].
CAS Number
2669070-40-8
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(OCO2)C2=C1)N(CC3=CSC(COC4=CC=C(F)C=C4)=N3)CC(C)C
Molecular Formula
C23H23FN2O4S
Molecular Weight
442.50
References & Citations
[1]MeiyangXi, et al. Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N- ((2- (p-tolyloxymethyl) thiazol-4yl) methyl) benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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