BuChE-IN-9

• Description :

  BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC50 of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase; Cholinesterase (ChE) ; GABA Receptor

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/buche-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN(C(CCN)C(NCC1=CC=CC=C1)=O)CCOCCN2C(C=CC=C3)=C3C4=C2C=CC=C4

• Molecular Formula :

  C28H34N4O2

• Molecular Weight :

  458.60

• References & Citations :

  [1]Paula Zaręba, et al. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. Eur J Med Chem. 2023 Oct 7:261:115832.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported