HDAC-IN-62

• Description:

  HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2 μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain[1].

• UNSPSC:

  12352005

• Target:

  Autophagy; HDAC

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Epigenetics

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hdac-in-62.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(/C=C/C1=CC=C(/C=C/C(NO)=O)N1C)C2=CC=CS2

• Molecular Formula:

  C15H14N2O3S

• Molecular Weight:

  302.35

• References & Citations:

  [1]Baek SY, et al. Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation. Biomed Pharmacother. 2023 Aug 9;166:115312.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported