HIV-1 protease-IN-9

HIV-1 protease-IN-9

• CAS Number: 2925381-27-5
• UNSPSC Description: HIV-1 protease-IN-9 (compound 5b) is a HIV-1 protease inhibitor, with a Ki of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC50 of 66.8 nM[1].
• Target Antigen: HIV Protease
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hiv-1-protease-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C=C(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CN(CC(C)C)S(=O)(C3=CC=C(N)C=C3)=O)=O)C=C1)NC4=NC=CC(C5=CN=CC=C5)=N4
• Molecular Weight: 679.83
• References & Citations: [1]Ghosh AK, et, al. Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. Eur J Med Chem. 2023 Jul 5;255:115385.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported