HIV-1 protease-IN-1

HIV-1 protease-IN-1

• CAS Number: 2765293-30-7
• UNSPSC Description: HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC50 value of 8.23 nM against C-HIV strain Indie[1].
• Target Antigen: HIV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hiv-1-protease-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@H]([C@@H](CN(S(C1=CC=C(C=C1)O)(=O)=O)CC(C)C)O)CC2=CC=CC=C2)[C@@H]3COCCN3
• Molecular Weight: 505.63
• References & Citations: [1]Zhu M, et al. Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C. Eur J Med Chem. 2022 Apr 5;233:114251.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported