HIV-1 protease-IN-5

HIV-1 protease-IN-5

• CAS Number: 2525173-96-8
• UNSPSC Description: HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants[1].
• Target Antigen: HIV Protease
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hiv-1-protease-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H](CN(S(=O)(C1=CC=C(C=C1)C(F)(F)F)=O)C[C@H]([C@@H](NC(C2=CC(O)=C(C=C2)O)=O)CC3=CC=CC=C3)O)O
• Molecular Weight: 582.59
• References & Citations: [1]Zhu M, et al. Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1' ligand to enhance binding with S1' subsite. Bioorg Med Chem. 2020 Aug 15;28(16):115623.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported