HIV-1 protease-IN-7

• UNSPSC Description:

  HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM)[1].

• Target Antigen:

  HIV Protease

• Type:

  Peptides

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hiv-1-protease-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N[C@@H](CC(C)C)C(N[C@@H](CCC2CCCCC2)C(N[C@H](C(N([C@H](C(N[C@@H](C)C(N[C@H](C(OC)=O)C(C)(C)SCC(N[C@H](C(N[C@H](C(N3CCC[C@@](C(N[C@H]1C(C)C)=O)3C)=O)C(C)C)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)C)=O)CC(C)C)=O)=O

• Molecular Weight:

  1285.68

• References & Citations:

  [1]Kusumoto Y, et al. Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization. ACS Medicinal Chemistry Letters, 2022.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2916441-36-4