HIV-1 protease-IN-3

• UNSPSC Description:

  HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC50=71 nM; EC50=0.86 μM)[1].

• Target Antigen:

  HIV; HIV Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hiv-1-protease-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@](C2=CC=C(S(C)(=O)=O)C=C2O[C@@H](C)CO)(CCC(C)C)[C@@H](O)CN1CC3=CC=C(OC)C=C3

• Molecular Weight:

  519.65

• References & Citations:

  [1]Kojima E, et al. Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template. J Med Chem. 2022 Apr 28;65(8):6157-6170.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported