HIV-1 protease-IN-3

HIV-1 protease-IN-3

• UNSPSC Description: HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC50=71 nM; EC50=0.86 μM)[1].
• Target Antigen: HIV; HIV Protease
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hiv-1-protease-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1[C@@](C2=CC=C(S(C)(=O)=O)C=C2O[C@@H](C)CO)(CCC(C)C)[C@@H](O)CN1CC3=CC=C(OC)C=C3
• Molecular Weight: 519.65
• References & Citations: [1]Kojima E, et al. Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template. J Med Chem. 2022 Apr 28;65(8):6157-6170.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported