PHD2-IN-1

• Description :

  PHD2-IN-1 is a potent and orally active inhibitor of HIF prolyl hydroxylase 2 (PHD2) with an IC50 of 22.53 nM. PHD2-IN-1 can be used for anemia research[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/phd2-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CC=C(NCC(N2CCC(C3=CN=C(C(NCC(O)=O)=O)C(O)=C3)CC2)=O)C=C1

• Molecular Formula :

  C21H23ClN4O5

• Molecular Weight :

  446.88

• References & Citations :

  [1]Wu Y, et.al. Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia. J Med Chem. 2023 Jul 13;66 (13) :8545-8563.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2768219-28-7]