PHD2-IN-4

• Description:

  PHD2-IN-4 (compound 1) is a PHD2 inhibitor. PHD2-IN-4 inhibits PHD2 with an IC50 of 4 nM. PHD2-IN-4 is potential for chronic kidney disease research[1].

• UNSPSC:

  12352005

• Target:

  HIF/HIF Prolyl-Hydroxylase

• Related Pathways:

  Metabolic Enzyme/Protease

• Smiles:

  O=C (C1=C (O) C2=C (C=N1) N=C (C=C2) N3CCOCC3) NCC4=CC=C (C#N) C=C4

• Molecular Formula:

  C21H19N5O3

• Molecular Weight:

  389.41

• References & Citations:

  [1]Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67 (2) :1393-1405.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIF-1α

• CAS Number:

  2924181-60-0