PHD2-IN-4

• Description :

  PHD2-IN-4 (compound 1) is a PHD2 inhibitor. PHD2-IN-4 inhibits PHD2 with an IC50 of 4 nM. PHD2-IN-4 is potential for chronic kidney disease research[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Related Pathways :

  Metabolic Enzyme/Protease

• Smiles :

  O=C(C1=C(O)C2=C(C=N1)N=C(C=C2)N3CCOCC3)NCC4=CC=C(C#N)C=C4

• Molecular Formula :

  C21H19N5O3

• Molecular Weight :

  389.41

• References & Citations :

  [1]Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67 (2) :1393-1405.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIF-1α

• CAS Number :

  [2924181-60-0]