PHD2/HDACs-IN-1

PHD2/HDACs-IN-1

• CAS Number: 2339867-53-5
• UNSPSC Description: PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI)[1].
• Target Antigen: HDAC; HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/phd2-hdacs-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN=C(N2CCC(NC(C3=CN=C(N4N=CC=C4)NC3=O)=O)CC2)N=C1)NO
• Molecular Weight: 425.40
• References & Citations: [1]Wei H, et al. Novel PHD2/HDACs hybrid inhibitors protect against cisplatin-induced acute kidney injury. Eur J Med Chem. 2022;230:114115.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported