PHD2-IN-2

• Description :

  PHD2-IN-2 (Compound 12) is a PHD2 inhibitor, with an IC50 of 34.3 nM. PHD2-IN-2 has high erythropoietin (EPO) inducing activity, with an EC50 of 6.79 μM. PHD2-IN-2 can be used for the research of anemia, ischemia, and hypoxia[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/phd2-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(C(NCC(O)=O)=O)C2=NC=NN2C(C(CC3)CC4=C3C=CC=C4)=C1

• Molecular Formula :

  C19H18N4O4

• Molecular Weight :

  366.37

• References & Citations :

  [1]Tang HT, et al. Prolyl hydroxylase inhibitor and use thereof. WO2024061172A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported