PHD-IN-1

• Description :

  PHD-IN-1 (compound 80) is a potent inhibitor of PHD2, with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells, respectively[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/phd-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(C(NCC2=CN=C(C#N)C=C2)=O)N=CC3=C1C=CC(N4[C@]5([H])CN(C6CC6)[C@](C5)([H])C4)=N3

• Molecular Formula :

  C24H23N7O2

• Molecular Weight :

  441.49

• References & Citations :

  [1]Ding X, et al. 1,7-Naphthyridine derivatives as PHD inhibitors and their preparation. World Intellectual Property Organization, WO2023072246 A1. 2023-05-04.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2924182-31-8]