PHD-IN-1

• Description:

  PHD-IN-1 (compound 80) is a potent inhibitor of PHD2, with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells, respectively[1].

• UNSPSC:

  12352005

• Target:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/phd-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(C(NCC2=CN=C(C#N)C=C2)=O)N=CC3=C1C=CC(N4[C@]5([H])CN(C6CC6)[C@](C5)([H])C4)=N3

• Molecular Formula:

  C24H23N7O2

• Molecular Weight:

  441.49

• References & Citations:

  [1]Ding X, et al. 1,7-Naphthyridine derivatives as PHD inhibitors and their preparation. World Intellectual Property Organization, WO2023072246 A1. 2023-05-04.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2924182-31-8]