PHD-1-IN-1
CAT:
804-HY-136300-01
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PHD-1-IN-1
- CAS Number: 2009343-14-8
- UNSPSC Description: PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an "Arg367-out" pocket[1].
- Target Antigen: HIF/HIF Prolyl-Hydroxylase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Inflammation/Immunology; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/phd-1-in-1.html
- Smiles: N#CC1=CC=C(C2=CC=CC3=NC=NN23)C=C1
- Molecular Weight: 220.23
- References & Citations: [1]Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672.
- Shipping Conditions: Room Temperature