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Antitumor agent-86

CAT: 0804-HY-152774Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152774Size:1 Each
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Description
Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades[1].
CAS Number
2907704-65-6
UNSPSC
12352005
Target
Akt; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-86.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O
Molecular Formula
C29H31N5O2S
Molecular Weight
513.65
References & Citations
[1]Salem MM, et al. Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells. Sci Rep. 2022 Dec 22;12 (1) :22146.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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