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HDAC-IN-49

CAT: 0804-HY-151897Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151897Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-49.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN(CC(NCC2=CC=CC=C2)=O)C(C3=CC=C(N(C)C)C=C3)=O)C(F)=C1
Molecular Formula
C26H27FN4O4
Molecular Weight
478.52
References & Citations
[1]Nina Reßing, et al. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24;65 (22) :15457-15472.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC4; HDAC6

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