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HDAC6-IN-49

CAT: 0804-HY-169156Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169156Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC50 of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R) . HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models[1].
UNSPSC
12352005
Target
5-HT Receptor; Cholinesterase (ChE) ; HDAC; Histamine Receptor; Monoamine Oxidase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac6-in-49.html
Smiles
O=S(N1C2=CC=C(C=C2C=C1)OCCCN3CCCCC3)(C4=CC=C(C=C4)C(NO)=O)=O
Molecular Formula
C23H27N3O5S
Molecular Weight
457.54
References & Citations
[1]Toledano-Pinedo M, et al., Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases. J Med Chem. 2024 Sep 26;67 (18) :16533-16555.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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