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Antitumor agent-77

CAT: 0804-HY-151429Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151429Size:1 Each
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Description
Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].
CAS Number
2870703-21-0
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; COX; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-77.html
Solubility
10 mM in DMSO
Smiles
O=C1[O-][Pt+2]([NH3])([NH3])[O-]C(C12CC(C2)(C(F)(F)F)O)=O
Molecular Formula
C7H11F3N2O5Pt
Molecular Weight
455.25
References & Citations
[1]Liu F, et al. Design and biological features of platinum (II) complexes with 3-hydroxy-3- (Trifluoromethyl) cyclobutane-1,1-Dicarboxylate as a leaving ligand. Eur J Med Chem. 2022 Nov 15;242:114673.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; COX-2

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