Antitumor agent-73

• Description:

  Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-73.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-]

• Molecular Formula:

  C50H82BrO4P

• Molecular Weight:

  858.06

• References & Citations:

  [1]Wang L, et al. Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. ACS Med Chem Lett. 2022 Apr 19;13 (5) :786-791.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT3

• CAS Number:

  [2812356-72-0]