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Antitumor agent-73

CAT: 0804-HY-151286Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151286Size:1 Each
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Description
Antitumor agent-73 is a Diosgenin derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1].
CAS Number
2812356-72-0
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-73.html
Solubility
10 mM in DMSO
Smiles
C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-]
Molecular Formula
C50H82BrO4P
Molecular Weight
858.06
References & Citations
[1]Wang L, et al. Synthesis and Antitumor Activity of Diosgenin Hydroxamic Acid and Quaternary Phosphonium Salt Derivatives. ACS Med Chem Lett. 2022 Apr 19;13 (5) :786-791.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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